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US 2020/0377444 A1Published application
Aminoadamantyl nitrate compounds and their use to treat cns disorders
AssigneePanorama Research, Inc.
InventorsCyrus K. BECKER, Meenakshi S. VENKATRAMAN, Xiaoming ZHANG, James W. LARRICK
Life of this patent
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Abstract
The present disclosure provides adamantyl compounds having one or more amine groups and one or more nitrate groups. The aminoadamantyl nitrate compounds can be used to treat disorders of the central nervous system, including neurodegenerative and non-neurodegenerative diseases.
Claims20
A compound comprising a Formula I:
- wherein:
- R1 and R2 independently are a hydrogen, a halide, a linear or a branched alkyl, linear or branched heteroalkyl, a linear or a branched alkoxy, a linear or a branched —O-heteroalkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which can optionally be substituted;
- R3 and R4 independently are a hydrogen or a linear or a branched C1-C6 alkyl, or R3, R4 and the nitrogen atom to which they are attached form a 3-8-membered heterocyclic ring;
- R5 is a hydrogen or a linear or a branched C1-C6 alkyl;
- X is a bond, a linear or a branched -alkyl-, a linear or a branched -heteroalkyl-, a linear or a branched —O-alkyl-, a linear or a branched —O-heteroalkyl-, —(CH2)j-cycloalkyl-(CH2)k—, —(CH2)j-heterocyclyl-(CH2)k—, —(CH2)j-aryl-(O)h—(CH2)k— or —(CH2)j-heteroaryl-(O)h—(CH2)k—, each of which can optionally be substituted;
- Y is a —ONO2 or a
- m is 0, 1, 2, 3, 4 or 5;
- j is 0, 1, 2 or 3;
- k is 0, 1, 2 or 3;
- and
- h is 0 or 1;
- or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof.
9 more elements
A compound comprising, a Formula II:
- wherein:
- R1 and R2 independently are a hydrogen, a halide, a linear or a branched alkyl, a linear or a branched heteroalkyl, a linear or a branched alkoxy, a linear or a branched —O-heteroalkyl, a cycloalkyl, a heterocyclyl, an aryl, or a heteroaryl, each of which can optionally be substituted;
- R3 and R4 independently area hydrogen or a linear or a branched C1-C6 alkyl, or R3, R4 and the nitrogen atom to which they are attached form a 3-8-membered heterocyclic ring;
- R5 is a hydrogen or a linear or a branched C1-C6 alkyl;
- X is a bond, a linear or a branched -alkyl-, a linear or a branched -heteroalkyl-, a linear or a branched —O-alkyl-, a linear or a branched —O-heteroalkyl-, a —(CH2)j—, a cycloalkyl-(CH2)k—, a —(CH2)j-heterocyclyl-(CH2)k—, a —(CH2)j-aryl-(O)h—(CH2)k— or a —(CH2)j-heteroaryl-(O)h—(CH2)k—, each of which can optionally be substituted;
- Y is a —ONO2 or a
- m is 0, 1, 2, 3, 4 or 5;
- j is 0, 1, 2 or 3;
- k is 0, 1, 2 or 3;
- and
- h is 0 or 1;
- or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof.
9 more elements
Dependencies are inferred from the claim text.