Nanocarriers and their processing for diagnostics and therapeutics
AssigneeRhode Island Hospital
InventorsQian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich
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Abstract
The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
Claims24
A system for selective drug delivery to a bodily tissue comprising a rosette nanopiece composition comprising a cargo compound,
- wherein a positively-charged nanopiece composition with net positive charge at pH 7-7.5 localizes or penetrates a negatively-charged tissue;
- wherein wherein a negatively-charged or weakly positively-charged nanopiece composition with net negative charge or weak positive charge at pH 7-7.5 localizes or penetrates a positively-charged tissue.
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A method of treating a disease or disorder comprising administration of an effective amount of a rosette nanopiece, wherein said nanopiece comprises a compound of Formula I or Formula II.
A method of diagnosing a disease or disorder comprising administration of rosette nanopiece, wherein said nanopiece comprises a compound of Formula I or Formula II.
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Dependencies are inferred from the claim text.