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US 2020/0370122 A1Published application
Immune index methods for predicting breast cancer outcome
OwnerTong Zhouinventor
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OwnerTong Zhouinventor
Estimating the term…
Provided are methods for diagnosing and predicting the outcome of a breast cancer patient or related cancers. The methods include determining expression levels of a plurality of biomarkers (selected genes) related to immune function in a biological sample, such as tumor tissues or a body fluid such as blood, from the patient. The expression levels of the biomarkers are used to derive an index which can be used as an indicator predictive of cancer patient outcome. Overexpression of a plurality of biomarkers of the invention can be used to generate a score or value which has been demonstrated herein to be indicative of a good or better patient outcome. The index, generated by the methods of the invention can also be used to stratify cancer subtypes, and also can be combined with conventional clinical parameters to better inform clinical decisions.
A method for evaluating the prognosis of a cancer patient, comprising
A method for evaluating the prognosis of a cancer patient, comprising determining the expression levels of the RNA transcripts of at least six biomarkers selected from the group consisting of APOBEC3G, CCL5, CCR2, CD2, CD27, CD3D, CD52, CORO1A, CXCL9, GZMA, GZMK, HLA-DMA, IL2RG, LCK, PRKCB, PTPRC, SH2D1A (SeQ ID NOs:
A method for evaluating the prognosis of a breast cancer patient, comprising determining the expression levels from the group consisting of APOBEC3G, CCL5, CCR2, CD2, CD27, CD3D, CD52, CORO1A, CXCL9, GZMA, GZMK, HLA-DMA, IL2RG, LCK, PRKCB, PTPRC, SH2D1A in a sample comprising one or more than one cancer cell from said patient, normalized against the expression levels of a reference set of RNA transcripts in said sample, wherein overexpression of said biomarkers is indicative of a good or better prognosis, thereby evaluating the prognosis of said breast cancer patient.
A method for predicting a response of a breast cancer patient to a selected treatment, comprising determining the expression levels of the RNA transcripts or their expression products of at least six biomarkers selected from the group consisting of APOBEC3G, CCL5, CCR2, CD2, CD27, CD3D, CD52, CORO1A, CXCL9, GZMA, GZMK, HLA-DMA, IL2RG, LCK, PRKCB, PTPRC, SH2D1A (SEQ ID NOs:
A method for evaluating the prognosis of a breast cancer patient, comprising detecting expression of at least six biomarkers selected from the group consisting of APOBEC3G, CCL5, CCR2, CD2, CD27, CD3D, CD52, CORO1A, CXCL9, GZMA, GZMK, HLA-DMA, IL2RG, LCK, PRKCB, PTPRC, SH2D1A (SEQ ID NOs:1-17) in a sample from said patient, wherein overexpression of said biomarkers is indicative of a good or better prognosis.
A kit comprising of nucleic acid probes for at least 6 of the immune-related genes selected from the group consisting of APOBEC3G, CCL5, CCR2, CD2, CD27, CD3D, CD52, CORO1A, CXCL9, GZMA, GZMK, HLA-DMA, IL2RG, LCK, PRKCB, PTPRC, SH2D1A (see SEQ ID NOs:
Dependencies are inferred from the claim text.