Apoe promotor snp associated with risk of alzheimer's disease and the use thereof

A method for diagnosing MIC (minor cognitive impairment) or Alzheimer's disease or predicting the risk of MIC or Alzheimer's disease by determining genetic variations, which indicate the MIC or AD, from a sample isolated from a subject and comprising nucleic acids, wherein the method comprises steps of,

• (a) contacting the sample above with a reagent to confirm the presence or absence of the said genetic variations in genes encoding APOE E4 allele or genes selected from genetic products of the said genes encoding APOE E4 allele;
• and
• (b) contacting the sample above with a reagent to detect the presence or absence of the said genetic variations in genes encoding rs405509 T allele of APOE promotor or genes selected from genetic products of the said genes encoding APOE E4 allele;
• and wherein the presence of both genetic variations of APOE E4/E4 and rs405509 T/T indicates that the subject is a MIC or AD patient or indicates that the subject has a risk of MIC or AD disease.