Method of treating type ii diabetes and obesity and method of screening a medicament for the same
AssigneeTsinghua University
InventorsPeng LI, Qiqi LI
Life of this patent
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Abstract
The present invention provides a use of an agent for preparing a medicament for inhibiting microRNA-708. The medicament is used for at least one of the following: reducing intracellular triglyceride content, inhibiting differentiation of fat cells, resisting obesity, promoting insulin sensitivity, increasing respiratory metabolic rates, increasing energy consumption, increasing the number of mitochondria, up-regulating oxidative phosphorylation or heat-producing genes, relieving insulin resistance, resisting fatty liver and treating or preventing Type 2 diabetes.
Claims21
-13. (canceled)
A method of treating type II diabetes or obesity, comprising introducing to a subject in need thereof a therapeutically effective amount of a reagent for microRNA-708 inhibition.
A method of screening a medicament for type II diabetes and obesity, comprising
- contacting a candidate medicament with a disease model,
- wherein microRNA-708 inhibition in the disease model after the contact is an indicator of the candidate medicament being a target medicament.
Dependencies are inferred from the claim text.