Malignant hematopoietic cell microcompartment and method for preparing such a microcompartment
AssigneesUniversite De Bordeaux, Centre National De La Recherche Scientifique, Inserm (Institut National De La Sante Et De La Recherche Medicale), Institut D'Optique Theorique Et Appliquee, Institut Bergonie, Universite De Rennes 1, Etablissement Francais Du Sang, Centre Hospitalier Universitaire (Chu) De Rennes
InventorsLAURENCE BRESSON-BEPOLDIN, SIMON LATOUR, ISABELLE MAHOUCHE, PIERRE NASSOY, KEVIN ALESSANDRI, KARIN TARTE, FRÉDÉRIC MOURCIN
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Abstract
The invention relates to a process for preparing cellular microcompartments comprising a hydrogel capsule surrounding a cluster of lymphomatous cells. The invention also relates to such a cellular microcompartment and the use thereof for screening anti-cancer molecules.
Claims25
1-20. (canceled)
A process for preparing a cellular microcompartment comprising an aggregate of cells containing malignant haematopoietic cells encapsulated in a hydrogel layer, wherein a hydrogel solution and a cell solution comprising malignant haematopoietic cells are concentrically coextruded and then crosslinked.
A cellular microcompartment comprising an aggregate of cells encapsulated in a hydrogel layer, wherein the aggregate of cells comprises malignant haematopoietic cells, and stromal cells, said microcompartment further comprising an extracellular matrix layer between the aggregate of cells and the hydrogel layer.
Dependencies are inferred from the claim text.