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US 2020/0369774 A1Published application
Il-6r antibody and antigen binding fragment thereof and medical use
AssigneesJiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
InventorsHua Ying, Houcong Jin, Qiyue Hu, Hu Ge, Yifang Wang, Weikang Tao
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Abstract
Provided in the present invention are an IL-6R antibody and antigen-binding fragment thereof. The IL-6R antibody is an alpaca-derived antibody, chimeric antibody and humanized antibody. Also provided in the present invention is the use of the antibody in the preparation of a drug for treating IL-6-related diseases.
Claims21
1-20. (canceled)
An anti- human IL-6R monoclonal antibody or antigen-binding fragment thereof comprising CDR1, CDR2 and CDR3, wherein
- the sequence of CDR1 is a sequence as set forth in SEQ ID NO:
- 15 or a variant sequence having 3, 2 or 1 amino acid differences from the sequence as set forth in SEQ ID NO:
- 15;
- the sequence of CDR2 is a sequence as set forth in SEQ ID NO:
- 16 or a variant sequence having 3, 2 or 1 amino acid differences from the sequence as set forth in SEQ ID NO:
- 16;
- and
- the sequence of CDR3 is a sequence as set forth in SEQ ID NO:
- 17 or a variant sequence having 3, 2 or 1 amino acid differences from the sequence as set forth in SEQ ID NO:
- 17.
7 more elements
Dependencies are inferred from the claim text.