Multispecific antigen binding proteins and methods of use thereof
AssigneeNanjing Legend Biotech Co., Ltd.
InventorsYafeng ZHANG, Chuan-Chu CHOU, Qi PAN, Shu WU, Shuai YANG
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Abstract
Provided are multispecific, such as trispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, a second antigen binding domain comprising a first single-domain antibody, and a third antigen binding domain comprising a second single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
Claims27
A multispecific antigen binding protein (MABP) comprising:
- (a) a first antigen binding portion comprising a heavy chain variable domain (VH) and a light chain variable domain (VL), wherein the VH and VL together form an antigen-binding site that specifically binds a first epitope,
- (b) a second antigen binding portion comprising a first single-domain antibody (sdAb) that specifically binds a second epitope, and
- (c) a third antigen binding portion comprising a second single-domain antibody (sdAb) that specifically binds a third epitope,
- wherein the first antigen binding portion, the second antigen binding portion, and the third antigen binding portion are fused to each other.
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Dependencies are inferred from the claim text.