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US 2020/0369754 A1Published application
Binding molecules that specifically bind to tau
AssigneeJanssen Vaccines & Prevention B.V.
InventorsConstantin APETRI, Jaroslaw JURASZEK, Cornelia Harmke VERVEEN, Roosmarijn JANSON, Bunga Berdien SIREGAR
Life of this patent
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Abstract
The invention relates to binding molecules and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The invention also relates to diagnostic, prophylactic and therapeutic methods using the binding molecules or antigen-binding fragments.
Claims23
A binding molecule that is capable of specifically binding to tau, selected from the group consisting of:
- a binding molecule comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2, a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3, a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 7, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6;
- a binding molecule comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 8, a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 9, a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 7, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6;
- a binding molecule comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 8, a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 10, a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 7, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6;
- a binding molecule comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 8, a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 9, a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 11, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 12;
- and
- a binding molecule comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 8, a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 10, a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 11, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 12.
33 more elements
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Dependencies are inferred from the claim text.