Engineered transferrin receptor binding polypeptides
AssigneeDenali Therapeutics Inc.
InventorsXiaocheng Chen, Mark S. Dennis, Mihalis Kariolis, Adam P. Silverman, Ankita Srivastava, Ryan J. Watts, Robert C. Wells, Joy Yu Zuchero
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Abstract
Provided herein are polypeptides that bind to a transferrin receptor, Fc dimers and fusion proteins comprising such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
Claims63
A polypeptide that specifically binds to a transferrin receptor, comprising a sequence having at least 85% sequence identity to the sequence of any one of SEQ ID NOS:83, 84, 191, 43, and 82, wherein the polypeptide comprises Glu at position 153, Tyr or Phe at position 157, Thr at position 159, Glu at position 160, Trp at position 161, Val, Ser, or Ala at position 162, Asn at position 163, Thr or Ser at position 186, Glu at position 188, Glu at position 189, and Phe at position 194, as numbered with reference to SEQ ID NO:1.
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Dependencies are inferred from the claim text.