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US 2020/0369698 A1Published application
Preparation of Metal-Pyridine Derivative Complexes for Use in Medical Imaging
AssigneeUniversity of Northumbria at Newcastle
InventorValery KOZHEVNIKOV
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Abstract
The present invention relates to methods of forming metal-pyridine derivative complexes using pericyclic reactions with metal-1,2,4-triazine derivative complexes and a dienophile as the reactants. The reactants are bioorthogonal and the methods are particularly useful in preparing imaging agents.
Claims28
A method of forming a pyridine;
- the method comprising:
- contacting a 1,2,4-triazine with a dienophile to form a pyridine;
- wherein the 1,2,4-triazine starting is complexed to the metal.
A kit for medical imaging or for imaging a biological sample, the kit comprising:
- a 1,2,4-triazine;
- and
- a dienophile;
- wherein the 1,2,4-triazine is complexed to a metal;
- and
- wherein either:
- A) the 1,2,4-triazine is attached to a biological targeting moiety;
- or
- B) the dienophile is attached to a biological targeting moiety.
6 more elements
Dependencies are inferred from the claim text.