Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases

A compound of formula I or formula II:

• wherein
• R1 is an optionally substituted bicyclic ring system;
• R2 is chosen from hydrogen, halogen, hydroxy, amino, cyano, (C1-C4)alkyl, (C1-alkoxy, (C1-C4)alkylamino, di(C1-C4)alkylamino, (C1-C4)acylamino, (C1-C4)fluoroalkyl, (C1-C4)fluoroalkoxy, and (C1-C6)oxaalkyl;
• one of X1 and X2 is chosen from —O—, and —N(QR5)—, and the other is —CR3R4—;
• Q is chosen from a direct bond, —CH2—, —C(═O)—, —C(═O)O—, —C(═O)NR6—, —SO2—, and —SO2NR6—;
• R3, R4, R6 and R7 are independently chosen from hydrogen and (C1-C6)alkyl;
• and
• R5 is chosen from hydrogen, (C1-C6)alkyl, hydroxy(C2-C6)alkyl, a three- to seven-membered carbocycle, and a three- to seven-membered heterocycle.