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US 2020/0369656 A1Published application
Inhibitors of camkk2 and uses of same
AssigneeNew York University
InventorsDan Sherman, Timothy J. Cardozo
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compounds suitable for inhibiting CaMKK2. Also provided are compositions and methods of treating diseases associated with CaMKK2.
Claims17
A compound having the following structure:
- where R9 is
- where R1 is chosen from halogens, substituted or unsubstituted aliphatic groups, substituted or unsubstituted benzyl groups, substituted or unsubstituted cycloalkyl groups, substituted or unsubstituted heterocycloalkyl groups, substituted or unsubstituted aryl groups, substituted or unsubstituted heteroaryl groups, CH═CHR6, —CCR6, —COR6, CO2R7, —CONHR7, CONR7R8, and —NHR6;
- Q1, Q2, and Q3 are independently chosen from C—H, C—F, or N;
- R2, R3, R4, and R5 are independently chosen from hydrogen, —CH3, —CH2CH3, benzyl groups, i-isopropyl groups, —CH2OH, —CH2NH2, —CH2NHR6, —CH2NR6R7, —CH2CONH2, —CH2CONHMe, —OR6, —(CH2)xOR6, —CH2CH2CH3, —CH2CH2OH, —CH2CH2NH2, —CH2CH2NHR6, —CH2CH2R6R7, —CH2CH2CONH2, and —CH2CH2CONHMe, wherein x is 1, 2, 3, 4, or 5;
- R6 is chosen from hydrogen, OH, alkyl groups, cycloalkyl groups, aryl groups, and heteroaryl groups, wherein R6 (except hydrogen) is optionally substituted with one or more R7 group;
- R7 and R8 are independently chosen from alkyl groups, hydroxyl groups, alkoxy groups, arylalkyl groups, substituted or unsubstituted heteroaryl groups, substituted or unsubstituted heterocyclyl groups, and substituted or unsubstituted heterocycloalkyoxy groups, wherein R7 and R8 can be combined to form a 3, 4, 5, 6, or 7 member ring;
- and
- X is chosen from C and S;
- Z is chosen from CH2, NH, NCH3, O, —OCH2—, and —CH2CH2—;
- and
- when X is C, then n is 1 and when X is S, then n is 2.
8 more elements
Dependencies are inferred from the claim text.