Tlr7/8 antagonists and uses thereof

A compound of formula I,

• or a pharmaceutically acceptable salt thereof, wherein,
• Ring A is an aryl having 6 atoms;
• Ring B is a heteroaryl having 2 nitrogen atoms, each nitrogen having a double bond to an adjacent carbon;
• R1 is —CN;
• each R2 is independently —H, —R, halogen, -haloalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
• each R3 is independently —H, —R, halogen, -haloalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
• each R4 is independently —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRC(O)OR, —NRSO2R, or —N(R)2;
• each R5 is independently —H, —R, halogen, -haloalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
• each R is independently hydrogen, C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur:
• each of which is optionally substituted;
• or
• two R groups on the same atom are taken together with the atom to which they are attached to form a C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur:
• each of which is optionally substituted;
• k is 0, 1 or 2;
• n is 0, 1, or 2;
• p is 0, 1, or 2;
• r is 1,2, or 3;
• and
• t is 1, 2, or 3;
• wherein k is 0 when attached to nitrogen;
• and k is 1 or 2 when attached to carbon.