Method for producing thiocarboxamidine salt compound
AssigneeKumiai Chemical Industry Co., Ltd.
InventorToshihiro Nagata
Life of this patent
Estimating the term…
Abstract
The present disclosure provides an industrially preferable, economical, and environmentally friendly method for producing a compound [C1] of formula (5), namely, a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound. The present disclosure relates to a method wherein: a reaction expressed by reaction formula [C2] is caused so as to produce a compound of formula (4) by reacting a compound of formula (3) with a halogenation agent in the presence of a nitrile solvent, and the compound of formula (4) is subsequently reacted with an isothiouronium-forming agent, thereby producing a compound of formula (5).
Claims26
A process for producing a compound of the formula (5):
- wherein R1 and R2 are each independently optionally substituted (C1-C6)alkyl;
- optionally substituted (C3-C6)cycloalkyl;
- optionally substituted (C2-C6)alkenyl;
- optionally substituted (C2-C6)alkynyl;
- optionally substituted (C1-C6)alkoxy;
- or optionally substituted phenyl;
- or
- R1 and R2, together with the carbon atom to which they are attached form a 4- to 12-membered carbocyclic ring, wherein the formed ring is optionally substituted,
- X is a halogen,
- which comprises the following steps (C) and (D):
- step (C):
- reacting a compound of the formula (3) with a halogenating agent in the presence of a nitrile solvent and a water solvent to produce a compound of the formula (4),
- wherein R1, R2 and X are as defined above,
- step (D):
- reacting the compound of the formula (4) with an isothiouronium-forming agent to produce the compound of the formula (5),
- wherein R1, R2 and X are as defined above.
(canceled)
Dependencies are inferred from the claim text.