Asymmetric derivatives of polyphenols of the dinaphthaline series, process of preparing and use thereof

A compound of general formula I

• or general formula II
• tautomeric forms, pharmaceutically acceptable salts and solvates thereof,
• wherein:
• R1 represents:
• C(O)H, C═N−R8, C═N−NH−R8, C═N−NH−C(O)R8;
• R8 represents:
• H;
• linear and branched C1-C20 alkyls, containing 0 to 10 substituents;
• linear and branched C2-C20 alkenyls and C2-C20 alkynyls with 1 to 9 double and (or) triple bonds, containing 0 to 10 substituents;
• unsubstituted and substituted cyclic systems with the number of atoms in the cycle of 3 to 20, containing 0 to 10 substituents, 0 to 10 double and (or) triple bonds, and 0 to 10 heteroatoms (N, S, O);
• unsubstituted and substituted aryls with 0 to 5 substituents;
• unsubstituted and substituted heteroaromatic compounds with the number of atoms in the cycle of 3 to 12 and the number of heteroatoms (N, S, O) of 1 to 6, containing 0 to 10 substituents;
• saturated, unsaturated and (or) aromatic polycyclic systems, containing 2 to 5 cycles with 3 to 8 atoms in the cycle, 0 to 10 double and (or) triple bonds and 0 to 10 heteroatoms (N, S, O), and 0 to 20 substituents;
• R2, R3, R2a, R3a, R7, R7a independently represent R8 or C(O)R8;
• R5 R5a independently represent H or N═N—R9;
• wherein R9 represents:
• unsaturated and saturated aryls with 0 to 5 substituents;
• unsaturated and saturated heteroaromatic compounds with the number of atoms in the cycle of 3 to 12 and the number of heteroatoms (N, S, O) of 1 to 6, containing 0 to 10 substituents;
• saturated, unsaturated and (or) aromatic polycyclic systems, containing 2 to 5 cycles with the number of atoms in the cycle of 3 to 8 and the number of heteroatoms of 0 to 10, and 0 to 20 substituents;
• R4, R4a, R6 R6a independently represent H, linear and branched C1-C10 alkyls;
• substituents represent H, F, Cl, Br, I, NO2, CN, SO3H, SO3M, SO2Cl, CF3, CCl3, CBr3, CI3, C(O)H, COOH, COOM, C(O)Cl, C(O)Br, C(O)I, R8, COOR8, C(O)R8, OH, OR8, OC(O)R8, OC(O)NR8R10, OSO2R8, NH2, NR8R10, N+(R8R10R11), NR8C(O)R10, NR8SO2R10, NR8C(O)NR10R11, SR8, S(O)R8, SO2R8, CH═NR8;
• R10, R11 independently represent:
• H;
• linear and branched C1-C20 alkyls, containing 0 to 10 substituents;
• linear and branched C2-C20 alkenyls and C2-C20 alkynyls with 1 to 9 double and (or) triple bonds, containing 0 to 10 substituents;
• unsaturated and saturated cyclic systems with the number of atoms in the cycle of 3 to 20, containing 0 to 10 substituents, with 0 to 10 double and (or) triple bonds and the number of heteroatoms (N, S, O) of 0 to 10;
• unsaturated and saturated aryls with 0 to 5 substituents, unsaturated and saturated heteroaromatic compounds with the number of atoms in the cycle of 3 to 12 and the number of heteroatoms (N, S, O) of 1 to 6, containing 0 to 10 substituents;
• saturated, unsaturated and (or) aromatic polycyclic systems, containing 2 to 5 cycles with the number of atoms in the cycle of 3 to 8, the number of double and (or) triple bonds of 0 to 10, and the number of heteroatoms (N, S, O) of 0 to 10, and 0 to 20 substituents;
• M represents Li, Na, K, Cs, Rb.