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US 2020/0369609 A1Published application
Compounds and Methods for Inhibiting CYP26 Enzymes
AssigneeQueen's University at Kingston
InventorsDonald Andrew Cameron, Martin Petkovich, Uttam Saha
Life of this patent
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Abstract
Compounds that are inhibitors of retinoic acid inducible P450 (CYP26) enzymes. The compounds have retinoid activity, are resistant to CYP26-mediated catabolism, act as inhibitors of CYP26B1, and are used for treating diseases that are responsive to retinoids.
Claims25
A compound of formula
- where A is a substituted or unsubstituted hydrophobic moiety,
- G is a moiety that comprises a substituted or unsubstituted heteroaryl group, or a moiety that comprises a substituted or unsubstituted aryl group and at least one heteroatom;
- R3 is independently H, halo, or a substituted or unsubstituted C1-C4,
- a dotted line is a bond that may be present or absent;
- n is 1 or 2,
- p is zero to 3,
- wherein a substituent is independently alkyl, aryl, halo, nitro, hydroxyl, amino, thiol, alkoxyl, amido, amide, boryl, carboxyl, alkenyl, allyl, cyano, substituted alkyl (e.g., alkylamino, halogenated alkyl), unsubstituted alkyl, or a combination thereof.
4 more elements
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
The pharmaceutical composition of claim 25, further comprising an excipient.
Dependencies are inferred from the claim text.