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US 2020/0368708 A1Published application
Stabilized colloidal crystals and methods of stabilizing colloidal crystals
AssigneeNorthwestern University
InventorsChad A. Mirkin, Seungkyu Lee, Cindy Yizhe Zheng, Katherine E. Bujold
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Abstract
Methods of stabilizing DNA-engineered crystals can include cross-linking the hybridized oligonucleotides. Stabilized crystals can have improved chemical and thermal stability.
Claims20
A method of stabilizing colloidal crystals, comprising:
- crystallizing oligonucleotides-functionalized nanoparticles under conditions sufficient to provide crystals having a target crystalline structure, and
- contacting the crystals with a cross-linking agent under conditions sufficient to cross-link the oligonucleotides and thereby provide stabilized crystals.
A colloidal crystal, comprising
- first nanoparticles functionalized with linker oligonucleotides and second nanoparticles functionalized with anchor oligonucleotides, the first and second particles being arranged in a crystalline structure through hybridization of the linker oligonucleotides and anchor oligonucleotides, the hybridized oligonucleotides being cross-linked, thereby stabilizing the crystals.
Dependencies are inferred from the claim text.