Intelligent control system, based on machine learning, to modulate end-tidal concentration levels through continuous adjustments in the volume and concentration of a flow of incoming respiratory gases (Gin) characterized by the fact that it is configured to sample and measure, in real time, a first of concentration and pressure signal (CP10) from the incoming gas flow (Gin) administered in a respiratory device (200) at a current breathing moment (T0 and a second concentration and pressure signal (CP20) of a respiration gas flow (GRESP) within the respiratory device (200) at the current respiratory moment (T0, the system being configured to estimate, in real time, and based on the first and second concentration and pressure signals (CP10, CP20) measured in the current moment of respiration (T0 and in the concentration and pressure signals (CP1n, CP2n) measured in prior respiratory moments (T-N), a new volume and a new concentration of oxygen and carbonic gas for the flow of incoming gases (Gin) for an immediate future inspiratory moment (Ti), the immediate future inspiratory moment (T1) occurring after the current respiratory moment (T0), the system being configured to adjust the volume and concentration of oxygen and carbonic gas of the flow of incoming gases (Gin) several times within the same inspiratory cycle.