Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal cpap device
AssigneeStamford Devices Limited
InventorsAndrew R. Clark, James B. Fink
Life of this patent
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Abstract
A method of delivering aerosolized surfactant to an infant that includes interfacing an aerosolization device with an airway of an infant and aerosolizing, using the aerosolization device, a volume of surfactant into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml/min. The surfactant is aerosolized within about 1 to 8 cm from a patient interface. Aerosol is generated for up to approximately 80% or each inspiration. The method also includes delivering the aerosolized surfactant to the infant's airway.
Claims40
An aerosolization system, comprising:
- a respiration system comprising an inspiratory limb and an expiratory limb;
- an aerosolization device, comprising:
- an aerosol chamber having a first end and a second end;
- an aerosol generator positioned at the first end of the aerosol chamber, wherein:
- the aerosol generator comprises a reservoir that is configured to receive a volume of liquid medicament for aerosolization by the aerosol generator;
- and
- the aerosol generator is configured to aerosolize the volume of medicament into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml/min;
- a patient interface that is positioned proximate the second end of the aerosol chamber;
- and
- a respiratory adaptor that is configured to couple the aerosolization system with the respiration system;
- at least one breath sensor that is configured to detect an inhalation of a patient;
- and
- a controller that is configured to actuate the aerosol generator to aerosolize the volume of medicament in synchronization with the detected inhalation.
A method of delivering aerosolized medicament to an infant, comprising:
- detecting an inhalation of an infant using one or more breath sensors;
- and
- aerosolizing, using an aerosolization device, a volume of medicament into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml/min based on the detected inhalation, wherein the medicament is aerosolized within about 1 to 8 cm from a patient interface.
A method of initializing an aerosolization system, comprising:
- connecting an aerosolization device with a controller, a respiration sensor, a medication source, and a respiration system;
- inputting a user's access credentials into the controller;
- inputting information associated with a patient and dose information into the controller;
- coupling the respiration sensor with a patient;
- priming the aerosolization device;
- and
- interfacing a patient interface with the patient's airways.
Dependencies are inferred from the claim text.