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AssigneeThe Trustees of the University of Pennsylvania
InventorsJames M. Wilson, William Thomas Rothwell, Christian Hinderer
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A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.
A composition comprising at least one AAV vector formulated for central nervous system delivery, wherein said composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier.
A composition comprising an AAV viral vector having an AAV9 capsid and having packaged therein an expression cassette encoding an anti-Her2 IgG antibody or a functional fragment thereof which comprises an anti-Her2 heavy chain which has disrupted binding for FcRn.
Dependencies are inferred from the claim text.