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US 2020/0368362 A1Published application
Improved process for the synthesis of linker-drug vc-seco-duba
AssigneeByondis B.V.
InventorsVladimir JANOUSEK, Martin KAS
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Abstract
The present invention relates to an improved process for the synthesis of linker-drug vc-seco-DUBA and its intermediates, as well as to the use of said improved process in a process for preparing an antibody-drug conjugate comprising the vc-seco-DUBA linker-drug.
Claims15
A compound of formula (II)
A process comprising reacting a compound of formula (III)
- with hydrogen chloride in 1,4-dioxane to form a compound of formula (II)
(canceled)
A process for the synthesis of vc-seco-DUBA of formula (I)
- comprising reacting a compound of formula (II)
- with a compound of formula (VII)
- to form the compound of formula (I).
Dependencies are inferred from the claim text.