Systems and methods for topical creams for warming

A topical delivery vehicle for application to the skin of a subject, the topical delivery vehicle comprising:

• a nitric oxide donor;
• one or more capsaicin compounds;
• a warming agent having an onset time of less than 1 minute;
• and
• a cooling agent,
• wherein the topical delivery vehicle has an ionic strength of at least 0.25 M, and is a cream, gel, lotion, or ointment.

A topical delivery vehicle for application to the skin of a subject, wherein at least about 80% by weight of the topical delivery vehicle comprises:

• water;
• sodium chloride and/or potassium chloride;
• L-arginine and/or L-arginine HCl;
• oleoresin of capsicum;
• vanillyl butyl ether;
• menthoxypropandiol;
• and
• an oil.

A topical delivery vehicle for application to the skin of a subject, the topical delivery vehicle being a cream and comprising:

• water;
• one or more ionic salts;
• one or more nitric oxide donors;
• oleoresin of capsicum;
• vanillyl butyl ether;
• menthoxypropandiol;
• an oil;
• one or more triglycerides;
• phenoxyethanol;
• one or more stearates;
• cetyl alcohol;
• and
• methylparaben and/or propylparaben.

A topical delivery vehicle for application to the skin of a subject, the topical delivery consisting essentially of:

• water;
• one or more ionic salts;
• one or more nitric oxide donors;
• oleoresin of capsicum;
• vanillyl butyl ether;
• menthoxypropandiol;
• an oil;
• one or more triglycerides;
• phenoxyethanol;
• one or more stearates;
• cetyl alcohol;
• and
• methylparaben and/or propylparaben.

A topical delivery vehicle for application to the skin of a subject, the topical delivery vehicle comprising each of the following compounds at concentrations that differ no more than +/−20% of the stated concentrations:

• water at a concentration of 30% to 75% by weight;
• sodium chloride and/or potassium chloride at a concentration of 5% to 15% by weight;
• L-arginine and/or L-arginine HCl at a concentration of 5% to 15% by weight;
• oleoresin of capsicum at a concentration of 0.1% to 5% by weight;
• vanillyl butyl ether at a concentration of 0.1% to 5% by weight;
• menthoxypropandiol at a concentration of 0.1% to 5% by weight;
• mineral oil at a concentration of 5% to 20% by weight;
• one or more triglycerides at a concentration of 1% to 10% by weight;
• one or more stearates at a concentration of 1% to 10% by weight;
• phenoxyethanol at a concentration of 0.1% to 5% by weight;
• and
• methylparaben and/or propylparaben at a concentration of 0.1% to 5% by weight.