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US 2020/0368352 A1Published application
Polymeric perfluorocarbon nanoemulsions for ultrasonic drug uncaging
OwnerRaag D. Airan, Qian Zhonginventors
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Abstract
Disclosed herein are compositions comprising polymeric perfluorocarbon nanoemulsions and methods of their production, as well as methods for their use in imaging, examination, diagnosis and/or treatment of neurological and psychiatric diseases, as well as for ultrasound- mediated localized drug release into the brain.
Claims19
A composition comprising a polymeric perfluorocarbon nanoemulsion comprising nanoparticles less than 1 micron in diameter, wherein the nanoparticles comprise:
- an amphiphilic diblock-copolymer;
- a high vapor pressure liquid core;
- and
- a hydrophobic compound selected from a therapeutic agent and a contrast agent.
1 more element
A method of producing a polymeric perfluorocarbon nanoemulsion, said method comprising:
- mixing an amphiphilic di-block copolymer and a hydrophobic compound selected from a therapeutic agent and a contrast agent in an organic solvent;
- transferring the mixture into normal saline or PBS and, subsequently, evaporating the organic solvent and to produce compound-loaded polymeric micelles;
- mixing the compound-loaded micelles with a high vapor pressure liquid;
- sonicating at 40 kHz until the high-vapor pressure liquid is emulsified forming a compound-loaded nanoemulsion of nanoparticles with a high vapor pressure liquid core;
- performing membrane extrusion to select for particles under 1 micron;
- and
- purifying the polymeric perfluorocarbon nanoemulsion by sequential centrifugation and resuspending in fresh aqueous medium.
4 more elements
Dependencies are inferred from the claim text.