Methods and compositions for preventing influenza infection
AssigneeThe University of Melbourne
InventorsMarios KOUTSAKOS, Katarzyna KEDZIERSKA, E. Bridie CLEMENS, Luca HENSEN
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Abstract
The present invention provides novel methods and compositions for use in preventing infection with at least one type of influenza virus, including the use of peptides or compositions comprising a peptide comprising, consisting or consisting essentially of an amino acid sequence selected from the group of sequences as shown in SEQ ID Nos: 1 to 53, or functional derivatives or homologues thereof.
Claims56
A composition comprising a peptide comprising, consisting or consisting essentially of an amino acid sequence selected from the group of sequences as shown in SEQ ID Nos:
- 1 to 53, or functional derivatives or homologues thereof.
A composition comprising at least one peptide comprising, consisting or consisting essentially of an amino acid sequence selected from the group of sequences consisting of SEQ ID Nos:
- 1 to 4, or functional derivatives or homologues of said peptides.
A composition comprising at least one peptide comprising, consisting or consisting essentially of an amino acid sequence selected from the group of sequences consisting of SEQ ID Nos:
- 5 to 19, and 43 to 53 or functional derivatives or homologues of said peptides.
A composition comprising at least one peptide comprising an amino acid sequence selected from the group of sequences consisting of SEQ ID Nos:
- 20 to 24, or functional derivatives or homologues of said peptides.
A composition comprising:
- a) a first peptide comprising an amino acid sequence selected from the group of sequences consisting of SEQ ID Nos:
- 1 to 4 and 25 to 42, and
- b) a second peptide comprising an amino acid sequence selected from the group of sequences consisting of SEQ ID Nos:
- 5 to 19, 25, 26 and 43 to 53, or functional derivatives or homologues of said peptides.
A composition comprising at least one peptide comprising, consisting or consisting essentially of an amino acid sequence selected from the group of sequences consisting of SEQ ID NOs:
- 9, 14, 25, 26, 33 and 40 or functional derivatives or homologues of said peptides.
A vaccine or immune stimulating composition for providing an immune response to an influenza virus in an individual, comprising:
- a) an immunogen in the form of at least one peptide comprising a sequence selected from the group of sequences consisting of SEQ ID NO:
- 1 to 53, and
- b) an adjuvant, for potentiating the immune response in an individual to the immunogen.
A method of eliciting an immune response in an individual to more than one subtype of influenza, the method comprising:
- administering to an individual an immune stimulating composition comprising an immunogen in the form of at least one peptide comprising, consisting or consisting essentially of an amino acid sequence selected from the group of sequences consisting of SEQ ID NO:
- 25, 26, 9, 33, 14, or 40,
- wherein preferably the peptide comprises, consists or consists essentially of the amino acid sequence of SEQ ID NO:
- 25, 33 or 40,
- thereby eliciting an immune response in the individual against more than one subtype of influenza.
Use of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1 to 53, or functional derivatives or homologues thereof, in the manufacture of a medicament for preventing an infection, or symptom of influenza infection in a subject.
A peptide comprising, consisting or consisting essentially of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1 to 53 or functional derivatives or homologues thereof.
A kit comprising a composition comprising a peptide that comprises, consists or consists essentially of an amino acid sequence selected from the group of sequences consisting of SEQ ID NO:
- 1 to 53, wherein optionally the kit comprises one or more cytokines and/or adjuvants in sealed containers.
Dependencies are inferred from the claim text.