Method of enhancing viral-mediated gene delivery
AssigneeWayne State University
InventorsZhuo-Hua PAN, Shengjie CUI, Gary ABRAMS
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Abstract
The invention provides methods for enhancing the delivery of viral vectors to the eye of a subject by administering a proteasome inhibitor or and a viral vector ending a gene of interest to the eye.
Claims21
A method of enhancing the delivery of a gene of interest to an eye of a subject comprising administering a proteasome inhibitor and a viral vector encoding the gene of interest to the eye.
12-14. (canceled)
A method of increasing light sensitivity or improving or restoring vision in a subject comprising administering a proteasome inhibitor and a viral vector that encodes an opsin to the vitreous of the eye.
A composition comprising a proteasome inhibitor and a viral vector that encodes a gene of interest.
Dependencies are inferred from the claim text.