System and methods to promote cellular regeneration following ischemia
AssigneeGeorgia State University Research Foundation, Inc.
InventorZhi-Ren LIU
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Abstract
Systems and methods for promoting cellular regeneration in ischemic tissue through administration of pyruvate kinase M2 or a substantially similar therapeutic to the ischemic tissue are disclosed herein.
Claims25
A method of promoting cellular regeneration to an ischemic tissue or a tissue damaged by ischemia, comprising administering a composition comprising a modified pyruvate kinase M2 (PKM2) to the ischemic tissue or a tissue damaged by ischemia, wherein the modified PKM2 has mutations from the wild-type PKM2 sequence that stabilize a dimer form of PKM2, wherein the protein is not a constitutive dimer of PKM2.
A method of promoting cellular regeneration to an ischemic tissue or a tissue damaged by ischemia, comprising administering a composition comprising a protein substantially similar or identical to wild-type pyruvate kinase M2 (PKM2) to the ischemic tissue or a tissue damaged by ischemia, wherein the ischemia is not cerebral ischemia in that the ischemia.
A modified PKM2 comprising at least two amino acid substitutions that result in increased dimer formation relative to and different from wild-type PKM2.
A system for promotion of cellular regeneration following ischemia comprising a pharmaceutical composition that further comprises a pyruvate kinase type M2 (PKM2), wherein the pharmaceutical composition is configured to contact an ischemic tissue and wherein the protein is in a pharmaceutically acceptable carrier.
(canceled)
Dependencies are inferred from the claim text.