Glycopeptide derivative compounds and uses thereof

A method for treating a bacterial pulmonary infection in a patient in need thereof, comprising administering to the lungs of a patient via a nebulizer, metered dose inhaler or a dry powder inhaler, a composition comprising an effective amount of a compound of Formula (II), or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 is C1-C18 linear alkyl, C1-C18 branched alkyl, R5—Y—R6—(Z)n, or
• R2 is —OH or —NH—(CH2)q—R7;
• R3 is H or
• R4 is H or CH2NH—CH2—PO3H2;
• n is 1 or 2;
• q is 1, 2, 3, 4, or 5;
• X is O, S, NH or H2;
• each Z is independently selected from hydrogen, aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocyclic;
• R5 and R6 are independently selected from the group consisting of alkylene, alkenylene and alkynylene, wherein the alkylene, alkenylene and alkynylene groups are optionally substituted with from 1 to 3 substituents selected from the group consisting of alkoxy, substituted alkoxy, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aminoacyloxy, oxyaminoacyl, azido, cyano, halogen, hydroxyl, carboxyl, carboxylalkyl, thioaryloxy, thioheteroaryloxy, thioheterocyclooxy, thiol, thioalkoxy, substituted thioalkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, heterocyclic, heterocyclooxy, hydroxyamino, alkoxyamino, nitro, —SO-alkyl, —SO-substituted alkyl, —SO-aryl, —SO-heteroaryl, —SO2-alkyl, —SO2-substituted alkyl, —SO2-aryl and —SO2-heteroaryl
• R7 is —N(CH2)2;
• —N(CH2)3;
• or
• Y is independently selected from the group consisting of oxygen, sulfur, —S—S—, —NR8—, —S(O)—, —SO2—, —OSO2—, —NR8SO2—, —SO2NR8—, —SO2O—, —P(O)(OR8)O—, —P(O)(OR8)NR—, —OP(O)(OR8)O—, —OP(O)(OR8)NR8—, —NR8C(O)NR8—, and —NR8SO2NR8—;
• and
• each R8 is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, aryl, heteroaryl and heterocyclic.