A method for regulating expression of PDGFC, FGF2, IGF1R, PTGIS, NOS3, EDN1, PLAT, PROC, VWF, F3, SERPINE1, IL-8, ICAM1, VCAM1, and CASP8 genes, comprising administering to a subject in need thereof a composition comprising an effective amount of a plant extract, wherein the plant extract comprises at least one combination selected from the group consisting of a grape seed extract and a Four seasons spring tea extract, a black tea extract and a spinach extract, a grape seed extract and a spinach extract, a grape seed extract and a green coffee bean extract, a red wine extract and a Pu-erh tea extract, and a grape seed extract and a Pu-erh tea extract.