Intestinal Protectant
AssigneesNational University Corporation Asahikawa Medical University, Sapporo Holdings Limited
InventorsYutaka Kohgo, Mikihiro Fujiya, Nobuhiro Ueno, Syuichi Segawa, Naoyuki Kobayashi
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Abstract
The present invention provides an intestinal tract protective agent comprising a polyphosphoric acid or a pharmaceutically acceptable salt thereof as an active ingredient.
Claims19
1-12. (canceled)
A method of inducing expression of heat shock protein 27 in a subject, comprising
- filtering polyphosphoric acids or pharmaceutically acceptable salts thereof with a 10 kDa cut-off filter thereby obtaining a polyphosphoric acid or a pharmaceutically acceptable salt thereof that does not pass through the filter, and
- administering to a subject in need thereof an effective amount of a composition comprising the polyphosphoric acid or the pharmaceutically acceptable salt thereof that does not pass through the filter,
- wherein the polyphosphoric acid is a linear chain polyphosphoric acid of formula (1) or a branched chain polyphosphoric acid having a branch which further bonds to the side chain of a linear chain polyphosphoric acid represented by formula (1):
- wherein n is an integer between 100 and 10,000.
The method according to claim 21, wherein the polyphosphoric acid-producing microorganism comprises one selected from the group consisting of Lactobacillus rhamnosus GG strain, Lactobacillus brevis SBC8803 strain, strains belonging to genera Lactobacillus, Bifidobacterium, Enterococcus, Lactococcus, Pediococcus, Leuconostoc, Streptococcus, Bacteroidetes, Eubacterium, and Clostridium.
A method of inducing expression of heat shock protein 27 in a subject, comprising
- administering to a subject in need thereof an effective amount of a composition comprising a polyphosphoric acid or a pharmaceutically acceptable salt thereof,
- wherein the polyphosphoric acid is a linear chain polyphosphoric acid of formula (1) or a branched chain polyphosphoric acid having a branch which further bonds to the side chain of a linear chain polyphosphoric acid represented by formula (1):
- wherein n is an integer between 100 and 10,000,
- wherein the composition excludes polyphosphoric acid which permeates a filtration membrane with a molecular weight cut off of 10 kDa.
Dependencies are inferred from the claim text.