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US 2020/0368288 A1Published application
Hierarchic Neural Microphysiological System for Brain Function and Disorders
AssigneeThe Trustees of Columbia University in the City of New York
InventorsRaju TOMER, Maria de los Angeles LOZANO
Life of this patent
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Abstract
A network of neurospheres (NNet) mimicking the small-world hierarchic-modular architecture of mammalian brains, created by synthetically building a network of inter-connected individual brain microphysiological systems (MPSs).
Claims21
-2. (canceled)
A method of making a neurosphere network, comprising:
- providing a plurality of neurospheres, optionally artificial neurospheres, on a surface of polysaccharide or of a silicone-based organic polymer, wherein the neurospheres are spaced apart on the surface by an average of 2, 5, 10, or 15 mm, and
- growing axons among neurospheres under culture conditions to form a neurosphere network.
-12. (canceled)
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-22. (canceled)
Dependencies are inferred from the claim text.