Angiopoietin-1- or vegf-secreting stem cell and pharmaceutical composition for prevention or treatment of cardiovascular disease, comprising same
AssigneeNsage Corp.
InventorsBonghee LEE, Delger Bayarsaikhan, Jaeseok LEE
Life of this patent
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Abstract
Disclosed are angiopoietin-1 (Ang-1)- or VEGF-secreting stem cells promotive of vascular formation, a generation method therefor, and a use thereof in preventing or treating cardiovascular disease.
Claims11
1-6. (canceled)
A method of vascular formation, comprising administering at least one mesenchymal stem cell selected from the group consisting of a VEGF-secreting mesenchymal stem cell and an Ang-1-secreting mesenchymal stem cell, or a culture of the mesenchymal stem cell, to a subject in need of vascular formation,
- wherein the VEGF-secreting mesenchymal stem cell contains a VEGF gene inserted thereinto and secrets VEGF, and the Ang-1-secreting mesenchymal stem cell contains an Ang-1 gene inserted thereinto and secrets Ang-1.
A method of inhibiting ischemic cell death, comprising administering at least one mesenchymal stem cell selected from the group consisting of a VEGF-secreting mesenchymal stem cell and an Ang-1-secreting mesenchymal stem cell, or a culture of the mesenchymal stem cells, to a subject in need of inhibiting ischemic cell death,
- wherein the VEGF-secreting mesenchymal stem cell contains a VEGF gene inserted thereinto and secrets VEGF, and the Ang-1-secreting mesenchymal stem cell contains an Ang-1 gene inserted thereinto and secrets Ang-1.
A method of preventing or treating a cardiovascular disease, comprising administering at least one mesenchymal stem cell selected from the group consisting of a VEGF-secreting mesenchymal stem cell and an Ang-1-secreting mesenchymal stem cell, or a culture of the mesenchymal stem cells, to a subject in need of preventing or treating a cardiovascular disease,
- wherein the VEGF-secreting mesenchymal stem cell contains a VEGF gene inserted thereinto and secrets VEGF, and the Ang-1-secreting mesenchymal stem cell contains an Ang-1 gene inserted thereinto and secrets Ang-1.
Dependencies are inferred from the claim text.