Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders
AssigneesOtsuka Pharmaceutical Co., Ltd., H. Lundbeck A/S
InventorsKenji MAEDA, Mai NAKAMURA
Life of this patent
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Abstract
A medicament comprising (I) brexpiprazole or a pharmaceutically acceptable salt thereof, and (II) nalmefene or a pharmaceutically acceptable salt thereof in combination, wherein brexpiprazole or a pharmaceutically acceptable salt thereof, and nalmefene or a pharmaceutically acceptable salt thereof are contained in a single preparation, or a pharmaceutical composition containing brexpiprazole or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing nalmefene or a pharmaceutically acceptable salt thereof are formulated for use in combination. The medicament is used for the prophylaxis or treatment of a substance-related disorder, preferably an alcohol-related disorder.
Claims6
1-20. (canceled)
A method for reducing alcohol consumption in patients with alcohol dependence, comprising administering to a subject in need thereof:
- (a) brexpiprazole or a pharmaceutically acceptable salt thereof and nalmefene or a pharmaceutically acceptable salt thereof, wherein the brexpiprazole or a pharmaceutically acceptable salt thereof and the nalmefene or a pharmaceutically acceptable salt thereof are contained in a single preparation;
- or
- (b) a pharmaceutical composition containing brexpiprazole or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing nalmefene or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical composition containing brexpiprazole or a pharmaceutically acceptable salt thereof and the pharmaceutical composition containing nalmefene or a pharmaceutically acceptable salt thereof are formulated for use in combination.
Dependencies are inferred from the claim text.