Methods of treating radiation induced gastrointestinal syndrome (rigs) and related disease states using yel002/bcn057

A method of treating radiation induced damage to epithelial cells in a subject in need thereof, the method comprising the step of administering to the subject a therapeutically effective amount of a compound of Formula I:

• wherein R1 and R2 are independently selected from the group consisting of hydrogen, amino, amide, F, Cl, Br, I, nitro, alkoxy, hydroxyl, thiol, alkylthio, acyl carboxylic acid, ester, sulfonyl, sulfonamide, —SO4H, optionally substituted C1-C20 alkyl, optionally substituted C1-C20 alkenyl, optionally substituted C1-C20 alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted phenyl;
• and
• wherein R3 is optionally substituted C1-C20 alkyl, optionally substituted C1-C20 alkenyl, optionally substituted C1-C20 alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocycloalkyl, optionally substituted heteroaryl, or optionally substituted phenyl.