Solid particle, preparation method therefor, and pharmaceutical composition containing solid particle
AssigneeShanghai Wd Pharmaceutical Co., Ltd
InventorsLiang Chang DONG, Wenbo MA, Lin WANG
Life of this patent
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Abstract
A solid particle, a preparation method therefor, and a pharmaceutical composition. The solid particle comprises a porous solid particle and a non-aqueous liquid formula. The non-aqueous liquid formula comprises 0.10-4.00 wt % of a hydrophobic active pharmaceutical agent, 28.00-99.90 wt % of a hydrophobic solubilizing solution, 0-70.00 wt % of a non-ionic surfactant, and 0-1.00 wt % of an antioxidant. The hydrophobic solubilizing solution comprises a medium-chain monoglyceride and diglyceride, and/or a propylene glycol fatty acid monoester.
Claims20
A solid microparticle, which comprises porous solid particles and a non-aqueous liquid formula, the non-aqueous liquid formula comprises 0.10% to 4.00% hydrophobic active pharmaceutical ingredient, 28.00% to 99.90% hydrophobic liquid solubilizer, 0 to 70.00% nonionic surfactant, and 0 to 1.00% antioxidant, the percentages refer to the weight percentages accounting for the non-aqueous liquid formula;
- and the hydrophobic liquid solubilizer comprises medium-chain mono-/di-glyceride, and/or propylene glycol fatty acid monoester.
Dependencies are inferred from the claim text.