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US 2020/0368204 A1Published application
Compounds for inhibiting ns3 and compositions containing the inhibited protein
AssigneeKing Abdulaziz University
InventorsMoustafa E. EL-ARABY, Abdelsattar Mansour Omar, Mahmoud Abdelkhalek El-Faky, Sameh Hamdy Abdelmageed Soror, Maan Talaat Khayat, Hani Zakariah Asfour, Faida Hassan Bamane
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Abstract
Imidazole-based compounds as hepatitis C virus (HCV) inhibitors. The compounds have an imidazole core that is disubstituted via amide links. Also described are a pharmaceutical composition incorporating the imidazole-based compound, a method of preparing these compounds, and a method for using the pharmaceutical composition in the treatment of HCV infection.
Claims8
1:
- A composition, comprising:
- non-structural protein 3 (NS3), and
- a compound of formula (I)
- a salt thereof, a solvate thereof, or a mixture thereof,
- wherein
- R1 is n-pentyl;
- and
- m is 4,
- wherein the compound of formula (I) is bonded to an active site of the NS3 to inhibit protease activity of the NS3.
6 more elements
2-12. (canceled)
13:
- The composition of claim 1, further comprising:
- a pharmaceutically acceptable carrier and/or excipient.
(canceled)
15:
- The composition of claim 13, wherein the pharmaceutically acceptable carrier and/or excipient is at least one selected from the group consisting of a buffer, an inorganic salt, a fatty acid, a vegetable oil, a synthetic fatty ester, a surfactant, and a polymer.
16:
- The composition of claim 13, further comprising an antiviral agent.
17-20. (canceled)
21:
- The composition of claim 13, further comprising a body fluid.
Dependencies are inferred from the claim text.