Glutaminase inhibitor therapy
AssigneeBoard of Regents, The University of Texas System
InventorsTimothy HEFFERNAN, Jeffrey KOVACS, Nakia SPENCER, Christopher BRISTOW
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Abstract
Disclosed herein are methods of treating a tumor or cancer in a subject whose tumor or cancer cells express low levels of asparagine synthetase (ASNS), and compounds and compositions useful in such treatment. Also disclosed herein are methods of evaluating whether to administer a compound that inhibits glutathione production or a glutaminase inhibitor to a subject with a tumor or cancer.
Claims28
A method of treating cancer in a subject whose cancer cells express low levels of asparagine synthetase (ASNS), as defined by an Histophathology Score (H-score) of less than or equal to 100 by immunohistochemical staining, comprising administering a glutaminase (GLS) inhibitor to said subject.
-5. (canceled)
Dependencies are inferred from the claim text.