Using probenecid to treat polycystic kidney disease
AssigneeMayo Foundation for Medical Education and Research
InventorsVicente E. Torres, Fouad T. Chebib, Peter C. Harris, Xiaofang Wang
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Abstract
This document provides methods and materials for treating polycystic diseases such as polycystic kidney disease. For example, methods for using a TRPV2 agonist (e.g., probenecid) and optionally a vasopressin receptor antagonist (e.g., tolvaptan) to treat a mammal having polycystic kidney disease (e.g., autosomal dominant polycystic kidney disease) are provided.
Claims21
A method of treating a mammal having polycystic disease, wherein said method comprises administering a composition comprising a TRPV2 agonist to said mammal under conditions wherein the severity of said polycystic disease is reduced.
A method of treating a mammal suspected of being at risk of developing polycystic disease, wherein said method comprises administering a composition comprising TRPV2 agonist to said mammal under conditions wherein the development of said polycystic disease is slowed.
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Dependencies are inferred from the claim text.