Methods of treatment
AssigneeArena Pharmaceuticals, Inc.
InventorsJohn W. ADAMS, Christen M. ANDERSON, William R. SHANAHAN
Life of this patent
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Abstract
Provided in some embodiments are methods of treating or preventing Raynaud's, comprising prescribing and/or administering to an individual in need thereof 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof.
Claims28
A method of treating or preventing Raynaud's, comprising:
- prescribing and/or administering to an individual in need thereof 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (Compound 1) or a pharmaceutically acceptable salt, hydrate, or solvate thereof.
The method of any one of the preceding claims, wherein the individual is administered an amount equivalent to 0.01 mg to 1.5 mg of Compound 1 daily.
The method of any one of the preceding claims, wherein the dose is administered once daily.
The method of any one of the preceding claims, wherein the Compound 1 or pharmaceutically acceptable salt, hydrate, or solvate thereof is administered via a titration scheme that comprises up-titration of the Compound 1 or pharmaceutically acceptable salt, hydrate, or solvate thereof.
The method of any one of the preceding claims, wherein the Compound 1 or pharmaceutically acceptable salt, hydrate, or solvate thereof is administered orally.
The method of any one of the preceding claims, wherein the Compound 1 or pharmaceutically acceptable salt, hydrate, or solvate thereof is in the form of a tablet.
The method of any one of the preceding claims, wherein the Compound 1 or pharmaceutically acceptable salt, hydrate, or solvate thereof is in the form of a capsule.
The method of any one of the preceding claims, wherein the Compound 1, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, is Compound 1.
The method of any one of the preceding claims, wherein treating comprises at least one of the following:
- a reduction in the frequency of attacks, a reduction in the severity of attacks, a reduction in ischemic tissue injury, and a reduction in digital ulceration.
The method of any one of the preceding claims, wherein treating comprises a reduction in the frequency and/or severity of attacks.
The method of any one of the preceding claims, wherein preventing comprises at least one of the following:
- the prevention of attacks, the prevention of ischemic tissue injury, and the prevention of digital ulceration.
Dependencies are inferred from the claim text.