Methods and devices for treating levodopa induced dyskinesia
OwnerAnubhav ARORA, Navdeep KAUR +3inventors
InventorsAnubhav ARORA, Navdeep KAUR, Guy DiPIERRO, Patrick H. RUANE, Ravinder D. PAMNANI
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Abstract
A method of delivering nicotine to treat dyskinesia, such as Levodopa induced dyskinesia (LID), includes delivering a first dose of nicotine to a patient using a transdermal delivery device and delivering a second dose of nicotine to the patient using the transdermal delivery device. The first and second doses are timed such that a refractory period between peak plasma levels of nicotine in the patient prevents desensitization of nicotinic acetylcholine receptors while reducing symptoms of LID.
Claims24
A method of delivering nicotine to treat Levodopa induced dyskinesia (LID), the method comprising:
- delivering a first dose of nicotine to a patient using a transdermal delivery device;
- and delivering a second dose of nicotine to the patient using the transdermal delivery device, the first and second doses timed such that a refractory period between peak plasma levels of nicotine in the patient prevents desensitization of nicotinic acetylcholine receptors while reducing symptoms of LID.
-35. (canceled)
A transdermal delivery device comprising:
- a formulation reservoir configured to hold a nicotine formulation therein;
- a transdermal membrane configured to deliver the nicotine formulation from the reservoir to the patient;
- and
- a sensor configured to detect one or more symptoms associated with Levodopa induced dyskinesia (LID).
Dependencies are inferred from the claim text.