Nucleic acid-containing lipid nanoparticle
AssigneeKyowa Kirin Co., Ltd.
InventorsKentaro HATANAKA, Michihiro MAEMOTO, Shintaro HOSOE
Life of this patent
Estimating the term…
Abstract
The present invention provides a nucleic acid-containing lipid nanoparticle comprising an analog of a fatty acid ester of glycerol, and a nucleic acid, wherein the analog is not hydrolyzable by a lipase.
Claims23
1-27. (canceled)
A nucleic acid-containing lipid nanoparticle comprising
- an analog of a fatty acid ester of glycerol, and
- a nucleic acid,
- wherein the analog is not hydrolyzable by a lipase.
A method for stabilizing a nucleic acid-containing lipid nanoparticle using an analog of a fatty acid ester of glycerol, wherein the analog is not hydrolyzable by a lipase.
A compound represented by formula (CL-XVIII), or a pharmaceutically acceptable salt thereof:
- wherein
- R137 and R138 are the same or different and are each linear or branched C8-C24 alkyl, C8-C24 alkenyl, C8-C24 alkynyl, C8-C24 alkylthioethyl, C8-24 alkenylthioethyl, or C8-C24 alkynylthioethyl;
- and
- X135 is a hydrogen atom, C1-C3 alkyl, hydroxy C2-C4 alkyl, formula (C):
- wherein X136 and X137 are the same or different and are each a hydrogen atom or C1-C3 alkyl, or X136 and X137 optionally form a C2-C6 nitrogen-containing hetero ring together with the nitrogen atom to which they are bonded;
- L132 is S or O;
- and p115 is an integer from 2 to 4,
- formula (D):
- wherein X138 and X139 are the same or different and are each a hydrogen atom or C1 to C3 alkyl, or X138 and X139 optionally form a C3-C6 nitrogen-containing hetero ring together with the nitrogen atom to which they are bonded;
- and p116 is an integer from 1 to 4,
- or formula (E):
- wherein X140 and X141 are the same or different and are each a hydrogen atom or C1 to C3 alkyl, or X140 and X141 optionally form a C3-C6 nitrogen-containing hetero ring together with the nitrogen atom to which they are bonded;
- and p117 is an integer from 1 to 4.
A compound represented by formula (CL-XIX), or a pharmaceutically acceptable salt thereof:
- wherein
- R139 and R140 are the same or different and are each linear or branched C8-C24 alkyl, C8-C24 alkenyl or C8-C24 alkynyl;
- L133 is S or O;
- and
- X142 is a hydrogen atom, C1-C3 alkyl, hydroxy C2-C4 alkyl, formula (F):
- wherein X143 and X144 are the same or different and are each a hydrogen atom or C1-C3 alkyl, or X143 and X144 optionally form a C2-C6 nitrogen-containing hetero ring together with the nitrogen atom to which they are bonded;
- L134 is S or O;
- and p118 is an integer from 2 to 4,
- or formula (G):
- wherein X145 and X146 are the same or different and are each a hydrogen atom or C1 to C3 alkyl, or X145 and X146 optionally form a C3-C6 nitrogen-containing hetero ring together with the nitrogen atom to which they are bonded;
- and p119 is an integer from 1 to 4.
Dependencies are inferred from the claim text.