Antifungal nanoparticles for targeted treatment of fungal infections
AssigneeBrown University
InventorsAnita Shukla, Sarah Cowles, Noel Vera-Gonzalez, Christina Bailey-Hytholt, Eli Silvert
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Abstract
The invention provides functionalized antifungal-loaded liposomal formulations targeting Candida, which minimize damage to healthy human cells, limit antimicrobial exposure, and reduce the development of antifungal resistance.
Claims20
A composition comprising a liposomal formulation and an antifungal.
A method of making a liposomal formulation, comprising the steps of a freeze-thaw, sonication, and extrusion method, wherein the liposomal formulation comprises the lipids hydrogenated soy phosphatidylcholine, cholesterol, phosphatidylglycerol, and α-tocopherol, and an antifungal selected from the group consisting of, but not limited to, anidulafungin, echinocandin B, cilofungin, micafungin, and caspofungin.
A method for treating a Candida infection, comprising the step of administering a liposomal formulation comprising an antifungal lipopeptide to a subject with a Candida infection.
Dependencies are inferred from the claim text.