Methods of treating eosinophilic esophagitis
OwnerBrian A. MELTZER, Gail M. COMERinventors
Life of this patent
Estimating the term…
Abstract
The present disclosure provides methods of treating inflammation of the upper gastrointestinal tract, especially the esophagus, by administering an oral corticosteroid. In some cases, the methods include treating eosinophilic esophagitis (EoE) by administering an oral corticosteroid in an induction phase and a maintenance phase to improve peak eosinophilic counts and symptoms. In embodiments, the methods include treating EoE by administering the oral corticosteroid at nighttime and/or while the patient is lying down.
Claims28
A method of topically treating eosinophilic esophagitis (EoE) in a patient in need thereof, comprising administering an effective amount of budesonide in an induction phase and a maintenance phase, wherein:
- an induction dose of about 1 mg to about 2 mg of budesonide is administered in the induction phase;
- and
- a maintenance dose of about 0.5 mg to about 1 mg of budesonide is administered in the maintenance phase.
A method of topically treating eosinophilic esophagitis (EoE) in a patient in need thereof, the method comprising:
- administering at least one induction dose of budesonide in an amount of about 1 mg to about 2 mg during an induction phase;
- and based upon patient response, subsequently administering at least one maintenance dose of budesonide in an amount of about 0.5 mg to about 1 mg during maintenance phase.
Dependencies are inferred from the claim text.