Glass vial with increased chemical stability

A glass vial, comprising:

• a base and a vial opening, the base comprising a boron-containing multicomponent glass, the glass vial holding a liquid active pharmaceutical ingredient formulation, the glass vial having a total volume of <4.5 mL, a filling level of the glass vial with the active pharmaceutical ingredient formulation is not more than 0.25 and a concentration of boron ions, measured at a measurement site below a plane of a middle of the glass vial using a concentration depth profile at a depth in a range from 10 to 30 nm, has a value, averaged over measurements of the concentration depth profile, that has an excess increase of not more than 30% compared to a concentration of boron ions measured using a concentration depth profile at a depth in a range from 10 to 30 nm with a measurement site in the plane of the middle of the glass vial, where the position of the plane of the middle of the glass vial is determined from an underside of the base of the glass vial in a direction of the vial opening.