Synergistic formulations for control and repellency of biting arthropods

A method for the control or repellency of biting arthropods, the method comprising bringing the biting arthropods into contact with a synergistic biting arthropod control or repellent formulation, wherein the synergistic biting arthropod formulation comprises:

• (I) any synergistic combination of two or more compounds (a), wherein compounds (a) are selected from the group consisting of:
• (1) alkyl ketones, saturated or unsaturated, branched or unbranched, containing from about 6 to about 18 carbon atoms, or any range of carbon atoms within said range;
• said alkyl ketones selected from the group consisting of geranyl acetone, farnesyl acetone, 2-tridecanone, methyl decyl ketone, alpha-ionone, beta-ionone, alpha-isomethylionone, isobutylionone, isolongifolen-9-one, dimethylionone, isolongifolanone, pseudoionone, 2-cyclopentylcyclopentanone, methyl nonyl ketone, and 3-decen-2-one;
• (2) cyclic compounds (A), branched or unbranched, saturated or unsaturated, containing from about 11 to about 20 carbon atoms, or any range of carbon atoms within said range;
• said cyclic compounds (A) selected from the group consisting of methyl jasmonate, methyl dihydrojasmonate, methyl dihydrojasmolate, ethyl dihydrojasmonate, ethyl dihydrojasmolate, propyl dihydrojasmonate, propyl dihydrojasmolate, prenyl dihydrojasmonate, prenyl dihydrojasmolate, methyl dihydrojasmodiol, methyl dihydrojasmonate amide, methyl dihydrojasmonate dimethyl ketal, apritone, apritol, methyl apritone, methyl apritol, tetrahydromethyl apritone, tetrahydromethyl apritol, 3-methyl-5-butyl-2-cyclohexenone, 3-methyl-5-isobutyl-2-cyclohexenone, 3-methyl-5-pentyl-2-cyclohexenone, 3-methyl-5-hexyl-2-cyclohexenone, 3-methyl-5-heptyl-2-cyclohexenone, 3-methyl-5-isobutyl-2-cyclohexen-1-ol, 3-methyl-5-heptyl-2-cyclohexen-1-ol, 3-methyl-5-(z-3-hexenyl)-2-cyclohexenone, 3-methyl-5-pentyl-2-cyclohexen-1-ol, farnesyl cyclopentanol, farnesyl cyclopentanone, amyl cyclopentanone propanone, gamma-dodecalactone, delta-dodecalactone, gamma-tridecalactone, gamma-tetradecalactone, delta-tetradecalactone, gamma methyl dodecalactone, gamma methyl tridecalactone, gamma-pentadecalactone, and gamma-heptadecalactone;
• (3) branched or unbranched, straight chain or cyclic, saturated or unsaturated, carboxylic acids containing from about 3 to about 18 carbon atoms or any range of carbon atoms within said range, including isomers thereof;
• said carboxylic acids selected from the group consisting of lactic acid, salicylic acid, geranic acid, citronellic acid, 3-methyl-2-decenoic acid, and any isomers thereof;
• and
• (4) esters of branched or unbranched, straight chain or cyclic, saturated or unsaturated, carboxylic acids containing from about 3 to about 18 carbon atoms or any range of carbon atoms within said range, including isomers thereof;
• said esters selected from the group consisting of methyl lactate, ethyl lactate, propyl lactate, butyl lactate, amyl lactate, isoamyl lactate, hexyl lactate, cis-3-hexenyl lactate, methyl geranate, ethyl geranate, isoamyl geranate, methyl citronellate, ethyl citronellate, methyl salicylate, ethyl salicylate, amyl salicylate, isoamyl salicylate, hexyl salicylate, cis-3-hexenyl salicylate, and any isomers thereof;
• (II) any synergistic combination of one or more of the compounds (a) with one or more repellents selected from the group consisting of N,N-diethyl-3-methylbenzamide (DEET®), para-menthane-3,8-diol (PMD), Picaridin, and other nitrogen containing repellents selected from amines, amides and nitrogen containing heterocyclic compounds;
• or
• (III) any synergistic combination of two or more repellents selected from the group consisting of N,N-diethyl-3-methylbenzamide (DEET®), para-menthane-3,8-diol (PMD), Picaridin, and other nitrogen containing repellents selected from amines, amides and nitrogen containing heterocyclic compounds;
• wherein the biting arthropods are selected from the group consisting of mosquitoes, bed bugs, biting flies, ticks, ants, fleas, biting midges, and spiders;
• wherein the synergistic combination comprising a combination of two or more compounds (a) of (I) or a combination of one or more compounds (a) and one or more repellants of (II) or a combination of two or more repellants of (III) produces, when biting arthropods are brought into contact with the synergistic formulation, a combined control or repellency effect, greater than the sum of the separate control or repellency effects, at essentially the same concentrations.

A synergistic biting arthropod control or repellent formulation comprising:

• (I) any synergistic combination of two or more compounds (a), wherein compounds (a) are selected from the group consisting of methyl dihydrojasmolate, propyl dihydrojasmolate, methyl dihydrojasmonate, propyl dihydrojasmonate, delta-dodecalactone, gamma-dodecalactone, apritone, methyl apritone, and lactic acid;
• or
• (II) any synergistic combination of one or more of the compounds (a) with one or more repellents selected from the group consisting of N,N-diethyl-3-methylbenzamide (DEET®), para-menthane-3,8-diol (PMD), Picaridin, and other nitrogen containing repellents selected from amines, amides and nitrogen containing heterocyclic compounds;
• wherein the biting arthropods are selected from the group consisting of mosquitoes, bed bugs, biting flies, ticks, and biting midges;
• wherein the synergistic combination comprising a combination of two or more compounds (a) of (I) or a combination of one or more compounds (a) and one or more repellants of (II) produces, when biting arthropods are brought into contact with the synergistic formulation, a combined control or repellency effect, greater than the sum of the separate control or repellency effects, at essentially the same concentrations.

A synergistic biting arthropod control or repellent formulation comprising:

• (I) any synergistic combination of two or more compounds (a), wherein compounds (a) are selected from the group consisting of:
• (1) alkyl ketones, saturated or unsaturated, branched or unbranched, containing from about 6 to about 18 carbon atoms, or any range of carbon atoms within said range;
• said alkyl ketones selected from the group consisting of geranyl acetone, farnesyl acetone, 2-tridecanone, methyl decyl ketone, alpha-ionone, beta-ionone, alpha-isomethylionone, isobutylionone, isolongifolen-9-one, dimethylionone, isolongifolanone, pseudoionone, 2-cyclopentylcyclopentanone, methyl nonyl ketone, and 3-decen-2-one;
• (2) cyclic compounds (A), branched or unbranched, saturated or unsaturated, containing from about 11 to about 20 carbon atoms, or any range of carbon atoms within said range, said cyclic compounds (A) selected from the group consisting of methyl jasmonate, methyl dihydrojasmonate, methyl dihydrojasmolate, ethyl dihydrojasmonate, ethyl dihydrojasmolate, propyl dihydrojasmonate, propyl dihydrojasmolate, prenyl dihydrojasmonate, prenyl dihydrojasmolate, methyl dihydrojasmodiol, methyl dihydrojasmonate amide, methyl dihydrojasmonate dimethyl ketal, apritone, apritol, methyl apritone, methyl apritol, tetrahydromethyl apritone, tetrahydromethyl apritol, 3-methyl-5-butyl-2-cyclohexenone, 3-methyl-5-isobutyl-2-cyclohexenone, 3-methyl-5-pentyl-2-cyclohexenone, 3-methyl-5-hexyl-2-cyclohexenone, 3-methyl-5-heptyl-2-cyclohexenone, 3-methyl-5-isobutyl-2-cyclohexen-1-ol, 3-methyl-5-heptyl-2-cyclohexen-1-ol, 3-methyl-5-(z-3-hexenyl)-2-cyclohexenone, 3-methyl-5-pentyl-2-cyclohexen-1-ol, farnesyl cyclopentanol, farnesyl cyclopentanone, amyl cyclopentanone propanone, gamma-dodecalactone, delta-dodecalactone, gamma-tridecalactone, gamma-tetradecalactone, delta-tetradecalactone, gamma methyl dodecalactone, gamma methyl tridecalactone, gamma-pentadecalactone, and gamma-heptadecalactone;
• (3) branched or unbranched, straight chain or cyclic, saturated or unsaturated, carboxylic acids containing from about 3 to about 18 carbon atoms or any range of carbon atoms within said range, including isomers thereof;
• said carboxylic acids selected from the group consisting of lactic acid, salicylic acid, geranic acid, citronellic acid, 3-methyl-2-decenoic acid, and any isomers thereof;
• and
• (4) esters of branched or unbranched, straight chain or cyclic, saturated or unsaturated, carboxylic acids containing from about 3 to about 18 carbon atoms or any range of carbon atoms within said range, including isomers thereof;
• said esters selected from the group consisting of methyl lactate, ethyl lactate, propyl lactate, butyl lactate, amyl lactate, isoamyl lactate, hexyl lactate, cis-3-hexenyl lactate, methyl geranate, ethyl geranate, isoamyl geranate, methyl citronellate, ethyl citronellate, methyl salicylate, ethyl salicylate, amyl salicylate, isoamyl salicylate, hexyl salicylate, cis-3-hexenyl salicylate, and any isomers thereof;
• (II) any synergistic combination of one or more of the compounds (a) with one or more repellents selected from the group consisting of N,N-diethyl-3-methylbenzamide (DEET®), para-menthane-3,8-diol (PMD), Picaridin, and other nitrogen containing repellents selected from amines, amides and nitrogen containing heterocyclic compounds;
• or
• (III) any synergistic combination of two or more repellents selected from the group consisting of N,N-diethyl-3-methylbenzamide (DEET®), para-menthane-3,8-diol (PMD), Picaridin, and other nitrogen containing repellents selected from amines, amides and nitrogen containing heterocyclic compounds;
• wherein the biting arthropods are selected from the group consisting of mosquitoes, bed bugs, biting flies, ticks, ants, fleas, biting midges, and spiders;
• wherein the synergistic combination comprising a combination of two or more compounds (a) of (I) or a combination of one or more compounds (a) and one or more repellants of (II) or a combination of two or more repellants of (III) produces, when biting arthropods are brought into contact with the synergistic formulation, a combined control or repellency effect, greater than the sum of the separate control or repellency effects, at essentially the same concentrations.