Combination product comprising dicycloplatin and preparation method and use thereof
AssigneeMedoncare Pharmaceutical Co., Ltd.
InventorsXiaozhong LIU, Xiong LI, Qifeng JIN, Hexiao ZHENG
Life of this patent
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Abstract
The present invention relates to the compositions containing dicycloplatin, pharmaceutical use of the compositions in the treatment and/or prevention of pain, inflammation and virus-related diseases, and methods of preparing the compostions thereof.
Claims32
A combination product comprising dicycloplatin and an acid, wherein the acid is selected from one or more of the following:
- 1,1-cyclobutanedicarboxylic acid, citric acid, chlorogenic acid, ferulic acid, Maleic acid, salicylic acid, folic acid and gallic acid, wherein the ratio of dicycloplatin to the acid is 1:0.01 to 1:99.
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A combination product comprising dicycloplatin and one or more of the following additional components:
- coenzyme Q10, curcumin, glutathione, oryzanol, citric acid, vitamin C, and anthocyanins, wherein the ratio of dicycloplatin to the additional components is about 0.1:1 to about 100:1.
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A method of treating and/or preventing pain, the method comprising administering an effective dose of dicycloplatin to a patient in need thereof.
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A method of treating and/or preventing tissue edema, or inflammation, comprising administering an effective dose of dicycloplatin to a patient in need thereof.
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A method of treating and/or preventing a disease associated with a viral infection, comprising administering an effective dose of a pharmaceutical composition to a patient in need thereof, wherein the pharmaceutical composition comprises dicycloplatin and glutathione.
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A method for preparing dicycloplatin or a composition comprising dicycloplatin and 1,1-cyclobutanedicarboxylic acid, the method comprising 1) stirring carboplatin and 1,1-cyclobutanedicarboxylic acid in a molar ratio of 1:1.05 to 1:99 in a suitable solvent, at room temperature or under heat, for an appropriate amount of time to obtain a mixture containing dicycloplatin and 1,1-cyclobutanedicarboxylic acid, and optionally 2) lyophilizing the obtained mixture directly, concentrating the mixture, adding an appropriate amount of water to dissolve it thoroughly, and then lyophilizing the mixture, or formulating the mixture into a desired aqueous solution, thereby obtaining the composition containing dicycloplatin and 1,1-cyclobutanedicarboxylic acid.
Dependencies are inferred from the claim text.