Electrochemical flash fluorination and radiofluorination
AssigneeThe Regents of the University of California
InventorsSaman Sadeghi, Mehrdad Balandeh
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Abstract
Provided herein are methods of fluorinating organic compounds. The electrochemical fluorination and radiofluorination of organic molecules using the cation pool technique is described, where the 18F and/or 19F-fluorine ions are added after the process of electrochemical oxidation, i.e., after formation of a carbocationic organic compound (i.e., a compound having a carbon atom with a positive charge).
Claims45
A method of producing a fluorinated organic compound, the method comprising the steps of:
- performing electrochemical oxidation on the organic compound, thereby forming a carbocation within the organic compound;
- (ii) adding a fluorinated nucleophile to the carbocation, thereby forming the fluorinated organic compound.
An electrolytic apparatus comprising a cathode chamber, an anode chamber, a carbocation within an organic compound, and a fluorinated nucleophile.
The apparatus of claim 39, wherein the anode chamber comprises the carbocation within the organic compound and the fluorinated nucleophile.
Dependencies are inferred from the claim text.