Preservation of pancreatic islet grafts in the extrahepatic space
AssigneesThe Regents of the University of California, U.S. Government as represented by the Department of Veterans Affairs
InventorsCasey WARD, Qizhi TANG, Peter STOCK, Gaetano FALEO, Gopika NAIR, Mathias HEBROK, Wenhan CHANG, Linda Thuy VO, Jeffrey A. BLUESTONE, Eleonora DE KLERK
Life of this patent
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Abstract
Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.
Claims57
A method for treating diabetes mellitus in an individual in need thereof, comprising co-transplanting a therapeutically effective amount of an insulin-producing cell and a cell derived from a parathyroid gland into the individual, thereby treating diabetes mellitus.
A method for treating diabetes mellitus in an individual in need thereof, comprising co-transplanting a therapeutically effective amount of an insulin-producing cell and a CD34+ cell derived from a parathyroid gland into the individual, thereby treating diabetes mellitus.
A method for treating diabetes mellitus in an individual in need thereof, comprising (a) isolating a CD34+ cell from a parathyroid gland;
- and (b) co-transplanting a therapeutically effective amount of the isolated CD34+ cell and an insulin-producing cell into the individual, thereby treating diabetes mellitus.
A method for engrafting an insulin-producing cell into an individual, comprising co-transplanting an insulin-producing cell and a cell derived from a parathyroid gland into the individual, thereby engrafting the insulin-producing cell into the individual.
A catheter comprising (a) an insulin-producing cell and (b) a cell derived from a parathyroid gland and/or a CD34+ cell.
A cannula comprising (a) an insulin-producing cell and (b) a cell derived from a parathyroid gland and/or a CD34+ cell.
A syringe comprising (a) an insulin-producing cell and (b) a cell derived from a parathyroid gland and/or a CD34+ cell.
A pharmaceutical composition comprising:
- (a) (i) a Stem Cell-Derived Insulin-Producing Cell (SCIPC);
- (ii) an enhanced Beta Cluster (eBC), and/or (iii) human islets;
- (b) a cell derived from a parathyroid gland and/or a CD34+ cell;
- and
- (c) one or more pharmaceutically acceptable excipients.
A method for treating diabetes mellitus in an individual in need thereof, comprising co-transplanting a therapeutically effective amount of a stem cell-derived pancreatic endocrine progenitor cell and a cell derived from a parathyroid gland into the individual, thereby treating diabetes mellitus.
A method for treating diabetes mellitus in an individual in need thereof, comprising co-transplanting a therapeutically effective amount of a stem cell-derived pancreatic beta cell and a cell derived from a parathyroid gland into the individual, thereby treating diabetes mellitus.
A method for treating diabetes mellitus in an individual in need thereof comprising co-transplanting a therapeutically effective amount of an insulin-producing cell and a CD34+ cell into the individual thereby treating diabetes mellitus.
Dependencies are inferred from the claim text.