Peptide inhibitors of insulin-degrading enzyme
AssigneeThe Regents of the University of California
InventorMalcolm A. Leissring
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Abstract
The present disclosure describes novel peptides, including peptides that inhibit the proteolytic activity of insulin-degrading enzyme (IDE). Also described are cosmetic and pharmaceutical formulations including these peptides, as well as a treatment method aimed at improving the appearance and/or texture of skin and/or promoting wound healing and a method for treating diabetes. The disclosed peptides and formulations are particularly useful for addressing the problem of impaired wound healing in diabetes.
Claims36
An isolated peptide or peptoid of, or corresponding to, 30 amino acid residues or less, wherein the peptide comprises or consists of a peptide amino acid sequence having at least 80% sequence identity to an amino acid sequence selected from the group consisting of:
- (SEQ ID NO:
- 1)
- QSLPWCYPHCVT,
- (SEQ ID NO:
- 2)
- VHWDFRQWWQPS,
- (SEQ ID NO:
- 3)
- ACSWWSIHLCG,
- and
- (SEQ ID NO:
- 4)
- WSPISGKFFQRF;
- or
- the peptoid corresponds to said peptide amino acid sequence.
Dependencies are inferred from the claim text.