Compositions and methods for treating cns disorders

A compound of Formula (I-II):

• or a pharmaceutically acceptable salt thereof, wherein
• m is 0, 1 or 2;
• X is —O—, —N(RX)—, or —S(O)y—, wherein RX is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, —S(O)2(RA0), —C(O)(RA0), or substituted or unsubstituted heteroaryl, wherein each instance of RA0 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, and y is 0, 1, or 2;
• R3a is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R19 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted C2-C6 alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl;
• R5 is hydrogen or methyl;
• each of R6a and R6b is independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl, or R6a and R6b are joined to form an oxo (═O) group;
• R1 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —SRA1, —N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)SRA1, —OC(═O)N(RA1)2, —SC(═O)RA2, —SC(═O)ORA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —NHC(═O)RA1, —NHC(═O)ORA1, —NHC(═O)SRA1, —NHC(═O)N(RA1)2, —OS(═O)2RA2, —OS(═O)2ORA1, —S—S(═O)2RA2, —S—S(═O)2ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, or two RA1 groups are joined to form an substituted or unsubstituted heterocyclic or heteroaryl ring;
• and RA2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• each of R15a, R15b, R16a and R16b is each independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —SRA1, —N(RA1)2, —CN(RA1)2, —C(O)RA1, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)SRA1, —OC(═O)N(RA1)2, —SC(═O)RA2, —SC(═O)ORA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —NHC(═O)RA1, —NHC(═O)ORA1, —NHC(═O)SRA1, —NHC(═O)N(RA1)2, —OS(═O)2RA2, —OS(═O)2ORA1, —S—S(═O)2RA2, —S—S(═O)2ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, —SO2RA2, —C(O)RA2, or two RA1 groups are joined to form an substituted or unsubstituted heterocyclic or heteroaryl ring;
• and
• RA2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or
• R15a and R15b or R16a and R16b are joined to form an oxo (═O) group;
• and
• each of R1a, R1b, R2a, R2b, R4a, R4b, R11a, R11b, R12a, and R12b is independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted alkynyl, —ORD1, —OC(═O)RD1, —NH2, —N(RD1)2, or —NRD1C(═O)RD1, wherein each instance of RD1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a nitrogen protecting group when attached to a nitrogen atom, or two RD1 groups are joined to form an substituted or unsubstituted heterocyclic ring;
• or any one of R2a and R2b, R4a and R4b, R11a and R11b, and R12a and R12b are joined to form an oxo (═O) group,
• when m is 0, then R1 is substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —SRA1, —N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)SRA1, —OC(═O)N(RA1)2, —SC(═O)RA2 SC(═O)ORA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —NHC(═O)RA1, —NHC(═O)ORA1, —NHC(═O)SRA1, —NHC(═O)N(RA1)2, —OS(═O)2RA2, —OS(═O)2ORA1, —S—S(═O)2RA2, —S—S(═O)2ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, or two RA1 groups are joined to form an substituted or unsubstituted heterocyclic or heteroaryl ring;
• and RA2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.

A compound of Formula (I-III):

• or a pharmaceutically acceptable salt thereof, wherein
• m is 0, 1 or 2;
• X is —O—, —N(RX)—, or —S(O)y—, wherein RX is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, —S(O)2(RA0), —C(O)(RA0), or substituted or unsubstituted heteroaryl, wherein each instance of RA0 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, and y is 0, 1, or 2;
• R3a is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• R1 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —SRA1, —N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)SRA1, —OC(═O)N(RA1)2, —SC(═O)RA2, —SC(═O)ORA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —NHC(═O)RA1, —NHC(═O)ORA1, —NHC(═O)SRA1, —NHC(═O)N(RA1)2, —OS(═O)2RA2, —OS(═O)2ORA1, —S—S(═O)2RA2, —S—S(═O)2ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, or two RA1 groups are joined to form an substituted or unsubstituted heterocyclic or heteroaryl ring;
• and RA2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• each of R15a, R15b, R16a and R16b is each independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —SRA1, —N(RA1)2, —CN(RA1)2, —C(O)RA1, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)SRA1, —OC(═O)N(RA1)2, —SC(═O)RA2, —SC(═O)ORA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —NHC(═O)RA1, —NHC(═O)ORA1, —NHC(═O)SRA1, —NHC(═O)N(RA1)2, —OS(═O)2RA2, —OS(═O)2ORA1, —S—S(═O)2RA2, —S—S(═O)2ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, —SO2RA1, —C(O)RA2, or two RA1 groups are joined to form an substituted or unsubstituted heterocyclic or heteroaryl ring;
• and
• RA2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or
• R15a and R15b or R16a and R16b are joined to form an oxo (═O) group;
• and
• each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, and R12b is independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted alkynyl, —ORD1, —OC(═O)RD1, —NH2, —N(RD1)2, or —NRD1C(═O)RD1, wherein each instance of RD1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a nitrogen protecting group when attached to a nitrogen atom, or two RD1 groups are joined to form an substituted or unsubstituted heterocyclic ring;
• or any one of R2a and R2b, R4a and R4b, R7a and R7b, R11a and R11b, and R12a and R12b are joined to form an oxo (═O) group.

A compound of Formula (I-IV):

• or a pharmaceutically acceptable salt thereof, wherein
• m is 0, 1, or 2;
• X is —O—, —N(RX)—, or —S(O)y—, wherein RX is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, —S(O)2(RA0), —C(O)(RA0), or substituted or unsubstituted heteroaryl, wherein each instance of RA0 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, and y is 0, 1, or 2;
• R3a is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen or methyl;
• each of R6a and R6b is independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl, or R6a and R6b are joined to form an oxo (═O) group;
• R1 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —SRA1, —N(RA1)2, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)SRA1, —OC(═O)N(RA1)2, —SC(═O)RA2, —SC(═O)ORA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —NHC(═O)RA1, —NHC(═O)ORA1, —NHC(═O)SRA1, —NHC(═O)N(RA1)2, —OS(═O)2RA2, —OS(═O)2ORA1, —S—S(═O)2RA2, —S—S(═O)2ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, or two RA1 groups are joined to form an substituted or unsubstituted heterocyclic or heteroaryl ring;
• and RA2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• each of R15a, R15, R16a and R16b is each independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —SRA1, —N(RA1)2, —CN(RA1)2, —C(O)RA1, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)SRA1, —OC(═O)N(RA1)2, —SC(═O)RA2, —SC(═O)ORA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —NHC(═O)RA1, —NHC(═O)ORA1, —NHC(═O)SRA1, —NHC(═O)N(RA1)2, —OS(═O)2RA2, —OS(═O)2ORA1, —S—S(═O)2RA2, —S—S(═O)2ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, —SO2RA2, —C(O)RA2, or two RA1 groups are joined to form an substituted or unsubstituted heterocyclic or heteroaryl ring;
• and
• RA2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or
• R15a and R15b or R16a and R16b are joined to form an oxo (═O) group;
• and
• each of R1a, R1b, R2a, R2b, R4a, R4b, R11a, R11b, R12a, and R12b is independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted alkynyl, —ORD1, —OC(═O)RD1, —NH2, —N(RD1)2, or —NRD1C(═O)RD1, wherein each instance of RD1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a nitrogen protecting group when attached to a nitrogen atom, or two RD1 groups are joined to form an substituted or unsubstituted heterocyclic ring;
• or any one of R2a and R2b, R4a and R4b, R11a and R11b, and R12a and R12b are joined to form an oxo (═O) group.

A compound of Formula (II-I):

• or a pharmaceutically acceptable salt thereof, wherein:
• n is 0, 1 or 2;
• each Xc is independently —C(R15a)(R15b)—, —O—, —N(RB1)—, —S—, —S(O)— or —S(O)2—, wherein RB1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, wherein one Xc is —O—, —N(RA1)—, —S—, —S(O)— or —S(O)2—;
• each of R15a and R15b is each independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —SRA1, —N(RA1)2, —N(RA1), —CN(RA1)2, —C(O)RA1, —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)SRA1 OC(═O)N(RA1)2, —SC(═O)RA2, —SC(═O)ORA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —NHC(═O)RA1, —NHC(═O)ORA1, —NHC(═O)SRA1, —NHC(═O)N(RA1)2, —OS(═O)2RA2, —OS(═O)2ORA1, —S—S(═O)2RA2, —S—S(═O)2ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, —SO2RA2, —C(O)RA2, or two RA1 groups are joined to form an substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclic or heteroaryl ring;
• and RA2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or R15a and R15b are joined to form an oxo (═O) group;
• R3a is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R19 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl;
• R5 is hydrogen or methyl, or when is a double bond, R5 is absent;
• each of R6a and R6b is independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl, or R6a and R6b are joined to form an oxo (═O) group;
• R1 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORA1, —SRA1, —N(RA1)2, —N(RA1), —OC(═O)RA1, —OC(═O)ORA1, —OC(═O)SRA1, —OC(═O)N(RA1)2, —SC(═O)RA2, —SC(═O)ORA1, —SC(═O)SRA1, —SC(═O)N(RA1)2, —NHC(═O)RA1, —NHC(═O)ORA1, —NHC(═O)SRA1, —NHC(═O)N(RA1)2, —OS(═O)2RA2, —OS(═O)2ORA1, —S—S(═O)2RA2, —S—S(═O)2ORA1, —S(═O)RA2, —SO2RA2, or —S(═O)2ORA1, wherein each instance of RA1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, or two RA1 groups are joined to form an substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclic or heteroaryl ring;
• and RA2 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, or R12b, is independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted alkynyl, —ORD1, —OC(═O)RD1, —NH2, —N(RD1)2, or —NRD1C(═O)RD1, wherein each instance of RD1 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a nitrogen protecting group when attached to a nitrogen atom, or two RD1 groups are joined to form an substituted or unsubstituted heterocyclic ring;
• or any one of R2a and R2b, R4a and R4b, R7a and R7b, R11a and R11b, and R12a and R12b are joined to form an oxo (═O) group;
• and
• wherein represents a single or double bond, provided if a double bond is present in Ring B, then one of R6a or R6b is absent.

A compound of Formula (II-II):

• or a pharmaceutically acceptable salt thereof, wherein:
• variables n R5, R19, R1, R1a, R1b, R2a, R3a, R2b, R4a, R4b, R6a, R6b, R7a, R7b, R11a, R11b, R12a, R12b, R15a and R15b are defined as in Formula II-I;
• and
• each Xa is independently —C(R15a)(R15b)—, —O—, —N(RA1)—, —N—, —S—, —S(O)— or —S(O)2—, wherein RA1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, wherein at least one Xa is —O—, —N(RA1)—, —S—, —S(O)— or —S(O)2—;
• wherein when at least one Xa is —O—, R3a is hydrogen, R19 is methyl, and R7a or R7b is hydroxyl, then R15a and R15b do not form oxo.

A compound of Formula (II-IIa):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• variables n R5, R19, R1, R1a, R1b, R2a, R2b, R4a, R4b, R6a, R6b, R7a, R7b, R11a, R11b, R12a, R12b, R15a and R15b are defined as in Formula II-I;
• and
• each Xa is independently —C(R15a)(R15b)—, —O—, —N(RA1)—, —N—, —S—, —S(O)— or —S(O)2—, wherein RA1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, wherein at least one Xa is —O—, —N(RA1)—, —S—, —S(O)— or —S(O)2—;
• and
• R3a is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.

A compound of Formula (II-III):

• or a pharmaceutically acceptable salt thereof, wherein:
• variables n R5, R19, R1, R1a, R1b, R2a, R2b, R3a, R4a, R4b, R6a, R6b, R7a, R7b, R11a, R11b, R12a, R12b, R15a, and R15b, are defined as in Formula II-I;
• and
• each Xb and Xb1 is independently —C(R15a)(R15b)—, —O—, —N—, —N(RA1)—, —S—, —S(O)— or —S(O)2— wherein RA1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, wherein at least one Xb or Xb1 is —O—, —N(RA1)—, —S—, —S(O)— or —S(O)2—.